Characterization of suspected dermal fillers containing. Comparative physical properties of hyaluronic acid dermal fillers en pdf. Until 2010, nearly every fdaapproved hyaluronic acid product in the united states did not contain lidocaine, thus significantly increasing the discomfort. Flynn tc, sarazin d, bezzola a, terrani c, micheels p. Hyaluronic acid fillers are examples of reversible dermal fillers because they may be completely removed with the use of hyaluronidase. Each is a clear gel formulation of hyaluronic acid specifically formulated to act like your bodys own naturally produced hyaluronic acid. One gram of hyaluronic acid can bind up to 6 l of water, and this binding occurs through the formation of a hydrogen bridge with the carboxyl group of the hyaluronic acid molecule. The restylane dermal filler gels resemble your bodys hyaluronic acid and are specifically designed to work within the different layers of the skin to replace or restore facial volume and improve the quality and integrity of your skin. Kablik j, monheit gd, yu lp, chang g, gershkovich j. The restylane family of products is a brand of hyaluronic acid dermal fillers, which includes restylane silk, restylane lyft, restylane, restylane refyne and restylane defyne. This is due in part to the wide portfolio of products available, ease of use, low overall complication profile, and reversibility. Histological evaluation over time of four hyaluronic acid. Hyaluronic acid ha dermal fillers are effective and safe for correction of facial rhytides.
Ha dermal fillers vary widely in their physical and chemical characteristics and many variables contribute to their overall performance. Ha fillers appear to be similar, but their physical characteristics can be. There are hundreds of types, but the market is dominated by hyaluronic acid fillers, which have by far the best safety profile. Clinical comparison between two hyaluronic acidderived. In vivo biointegration of three hyaluronic acid fillers in human skin. What are the long term effects of using hyaluronic acid.
Dermal fillers, lip fillers hyaluronic acid injections. Kablik j, monheit gd, yu l, chang g, gershkovich j. Hyaluronic acid ha is a sugarlike molecule that can be found in our skin and joints. Calcium hydroxylapatite, polyllactic acid, and polymethylmethacrylate. Figure figure1 1 displays the products by g the first habased filler approved for use in the united states. Hyaluronic acid is the filler that closely meets these characteristics, and consequently, is being increasingly used in everyday practice by dermatologists and plastic surgeons. This article explains the basic science of ha and describes how the physical properties of ha dermal fillers may influence clinical outcomes. The physical properties of commerciallyavailable dermal fillers containing ha were evaluated using rheologic testing methods under clinicallyrelevant conditions.
Polylactic acid is known to work particularly well in the lower half. Monheit, md,yz liping yu, phd, grace chang, and julia gershkovich. Application of hyaluronic acid in tissue engineering 1. Objective to investigate differences in the properties of dermal fillers that can be related to the respective cross. Hyaluronic acid ha is a linear naturally occurring polysaccharide formed from repeating.
Hyaluronic acid ha is a naturally occurring linear polysaccharide composed of repeating disaccharide units of nacetyldglucosamine and dglucuronate. Gel properties of hyaluronic acid dermal fillers request pdf. The gels tested demonstrated a broad range of elasticity, firmness and viscosity. This type of dermal filler is known as a stimulator. Comparative physical properties of hyaluronic acid dermal fillers.
This was a multicenter, doubleblinded, randomized, controlled, noninferiority clinical trial involving 88 subjects with moderate to. This study aimed to compare the efficacy, safety, and durability of a new hyaluronic acid gel biohyalux versus restylane for the correction of nlf. Ha is omnipresent in the human body and occurs in almost all biological tissues and fluids anderegg et al. This is because as you age, the reserves of natural hyaluronic acid in your body break down but these dermal fillers provide a suitable replacement. Since ha is also biodegradable and does not elicit an immune response, 9 it is now regarded by many as the most effective dermal filler substance. The fillers consist of crosslinked ha microspheres suspended in a noncrosslinked ha. Additionally, light microscopy was used to assess the particulate nature of each product. The four most commonly used dermal fillers at our practice are restylane, restylane lyft, juvederm and radiesse. Hyaluronic acid serums are great for adding hydration and mildly plumping your skin.
Dermal fillers are nonpermanent, putting you in control of the way you look. The biology of facial fillers facial plastic surgery. Hyaluronic acids and other dermal fillers have different properties and different injection requirements, resulting in different associated risks and long term effects. In terms of a generic classification of dermal fillers, it is helpful to separate them into 2 main classes. Hyaluronic acid has a heparinlike effect, thus resulting in a greater incidence of bruising than is seen with collagen fillers. Todays methods to quantify the amount of crosslinked ha are not very. Background hyaluronic acid ha fillers are becoming the material of choice for use in cosmetic soft tissue and dermal correction.
Rheological characteristics of hyaluronic acidbased dermal fillers. Dermal gel extra physical properties and clinical outcomes gary d. To extend the duration of has within the dermis and obtain the particle texturing feel, has are crosslinked to. Ha fillers appear to be similar, but their physical characteristics can be quite different. These differences have the potential to affect the ability of the physician to provide the patient with a natural and enduring result. Hyaluronic acid ha dermal biphasic fillers are synthesized for their efficacy in. Hyaluronic acid is a natural component found in the whole body 50% in the skin with high moisturising and remodelling properties. Clinical studies on dermal fillers have essentially focused upon visible improvement of skin quality and any eventual side effects, whereas very little is known about their detailed biological effects. Its used to restore facial contours and improve signs of aging. Biophysical and biological characterization of a new line.
Practical approach and safety of hyaluronic acid fillers. The first three are hyaluronic acid ha based dermal fillers and radiesse is a product that is made from calcium hydroxyapatite cha. In vitro resistance to degradation of hyaluronic acid dermal fillers by ovine testicular hyaluronidase. Thanks to its favourable biophysical properties, ha is used in a broad range of. Overall, dermal fillers have a relatively low risk of adverse side effects. Abstract background hyaluronic acid ha fillers are becoming the material of choice for use in cosmetic soft tissue and dermal correction. Biomedical application of hyaluronic acid nanoparticles. Hyaluronic acid is the filler that closely meets these. Juvederm is a cosmetic treatment referred to as a filler. Hyaluronic acidbased dermal fillers are currently among the most commonly used substances in cos. Rheological evaluation of the physical properties of. Dermal fillers have become one of the most popular tools in the fight against aging.
Dermal fillers are products injected under the skin to replace or augment volume in a way that aims to improve the aesthetics of the face. For those of you who dont know, a nonsurgical rhinoplasty treatment involves the contouring, reshaping, sculpturing and remodelling of the nasal framework without surgery, using absorbable and safe hyaluronic acid dermal fillers. However, the hyaluronic acid will not penetrate beneath the skin and add volume in the way that dermal fillers do. Hyaluronic acid ha has important applications in the field of orthopedics, ophthalmology and cosmetics. Hailed by some as liquid facelifts dermal fillers can instantly reduce many common aging related issues such as wrinkles, thinning lips, or hallowing cheeks, without the pain or necessary recovery time associated with cosmetic surgery. Rheological evaluation of the physical properties of hyaluronic. Effect of molecular weight of hyaluronic acid ha on. Because hyaluronic acid is identical in all species, the risk of allergy is remote. Results the results demonstrated that commercial fillers exhibit a wide variety of properties.
Most of the hyaluronic acid habased dermal fillers currently on the market are chemically modified with crosslinkers to improve the mechanical properties and duration in vivo. Clinical comparison of two hyaluronic acidderived fillers in the treatment of nasolabial folds. Clinical comparison of two hyaluronic acidderived fillers. Turnover and possible pathways for elimination of hyaluronic acid 1. The measured physical properties were concentration, geltofluid ratio, ha gel. The aim of the study is to provide biophysical and biological data that may support the clinical indications and allow to predict performance possibly with respect to. Dermal fillershyaluronic acid healthy skin clinic in phuket.
They all contain ha obtained through the fermentation of streptococcus sp. The mechanical properties and the particle texturing feel of the fillers made from crosslinked. Every company and every brand of hyaluronic fillers promises to be the best, to have the softest gel, and the longest lasting filler. Hyaluronic acid fillers are used to improve the appearance of nasolabial folds nlf. Dermal fillers cosmetic surgery ramsay health care. Naturally occurring dermal fillers, such as hyaluronic acid fillers are thought to be the safest.
Request pdf comparative physical properties of hyaluronic acid dermal fillers hyaluronic acid ha fillers are becoming the material of choice for use in. Comparative physical properties of hyaluronic acid dermal fillers jeffrey kablik, gary d. Hyaluronic acid ha dermal fillers are widely used to reduce the appearance of aging. Comparative physical properties of hyaluronic acid dermal. The hyaluronic acid used in the manufacture of fillers may be of animal origin, from the roosters crest, or nonanimal origin, obtained by biofermentation. Complications of injectable fillers, part i aesthetic. Due to a halflife of less than one day 50% of the total hyaluronic acid is degraded in less than a day, hyaluronic acid needs to be constantly renewed. It is important that you choose a qualified and experienced practitioner to advise you of the risks of your dermal filler. The present study aims at identifying alterations in the rheological properties of dif. Hyaluronic acid ha fillers are becoming the material of choice for use in cosmetic soft tissue and dermal correction. The hyaluronic acid fillers will add volume beneath the skin below the eyes, as well as triggering the production of fresh collagen and elastin.
In its natural state, hyaluronic acid ha exhibits poor biomechanical properties as a dermal fillers due to the poor viscoelasticity and the short halflife of ha when injected into normal skin. It has a tissue halflife of 12 days, being easily removed through enzymatic degradation in the liver to carbon dioxide and water. Efficacy and safety of a new resilient hyaluronic acid dermal filler, in the correction of moderate. Commerciallyavailable ha dermal fillers are similar in many respects. Polylactic acid is a synthetic dermal filler that is injected into your face, causing your bodys own production of collagen. Types of dermal fillers american society of plastic surgeons. Best dermal fillers my detailed analysis for which are currently the best hyaluronic acid dermal fillers and for which treatment. Aesthetic practitioner dr ravi jain is a proponent of nonanimal stabilised hyaluronic acid known as nasha, used in restylane filler products. The measured physical properties were concentration, gel. However, comparative research on the efficacy and safety of products of similar composition is limited. A wide variety of hyaluronic acid dermal filler options are available to you.